Check out these strategic global sourcing pictures:
RAF Merlin HC3A Helicopter of No28 Sqn
Image by Defence Pictures
A Royal Air Force Merlin HC3A helicopter is pictured in the course of a education flight over Oxfordshire, Buckinghamshire and Berkshire.
The Merlin (Bird of prey) HC3 and HC3a are operated by No.28 (AC) Squadron and 78 Squadron at RAF Benson.
No.78 Squadron was re-formed on 3 Dec 07 to allow for the boost in aircraft right after the buy of the 6 Danish Merlin HC3a earlier in 2007.
The Merlin is the very first of a new generation of advanced, medium support helicopters for the RAF. It is an all climate, day and night, multi-role helicopter utilized in both tactical and strategic operational roles.
The aircraft carries an impressive defensive-aids suite, which involves a Radar and Laser Warning Receiver, Missile Strategy Warners and Directional Infrared Countermeasures equipment, all integrated with an automatic chaff and flare dispensing technique.
This is a single of the most complete defensive aids suites fitted to any helicopter in the world. To ensure correct navigation anywhere on the globe, the aircraft’s management computers take information from its laser-gyro, inertial-navigation platform and its doppler system and from air data sources, and combine the information with precise position information received from Global Positioning System satellites.
Navigation at night is enhanced by the crew’s use of display evening-vision goggles and by the aircraft’s multi-function turret, which can be fitted with forward- looking infrared radar. To improve the aircraft’s variety, the Merlin can be equipped with extended range fuel tanks and is capable of air-to-air refuelling, although this choice is not presently utilized by the RAF. It is also fitted with an active vibration-damping technique, which reduces the level of noise and vibration inside the cabin to a level no greater than that of a turboprop aircraft. As a result, crew fatigue is considerably decreased for the duration of extended transits and airframe life is increased.
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母斑馬魚 Female Zebrafish-01_Worth US0 dollars
Image by 阿鶴
Thanks for the German AtmoSAFE Business choosing this zebrafish photo named "Female Zebrafish-01_Worth US dollars" on their official internet site homepage.
The homegape URL is " www.atmosafe.net/de.html ".
The application report is "Der Zebrafisch mag keinen Anxiety" and its URL is " www.atmosafe.net/de/anwendungen/bebrueten-und-zuechten/ze… "
Thanks for the Anaspec Business selecting this zebrafish photo named "Female Zebrafish-01_worth US dollars" on one particular Z-Fish Antibodies ad in the 2011 zebrafish meeting brochure (www.union.wisc.edu/zebrafish/).
The zebrafish meeting is "4th Strategic Conference of Zebrafish Investigators" to be held January 29th – February 2nd, 2011 at Asilomar Conference Center in Pacific Grove, California.
Thanks for the Notre Dame University’s NDeRC (Notre Dame extended Analysis Neighborhood) choose this photo as the primary photo along their BioEyes website (erc.nd.edu/blogs/bioeyes/) and thier Collaborations site (erc.nd.edu/collaborations/).
Thanks for the "Lin Li-Yih Lab"* supplied the zebrafish.
* Lin Li-Yih Lab, The Division of Life Science, The National Taiwan Normal University, ROC.
The following descriptions of zebrafish quote from wikipedia internet site (URL: en.wikipedia.org/wiki/Zebrafish). All Rights are belonging to "Wikipedia web site".
1.Introduce: The zebrafish, Danio rerio, is a tropical freshwater fish belonging to the minnow loved ones (Cyprinidae). It is a well-known aquarium fish, frequently sold below the trade name zebra danio, and is an crucial vertebrate model organism in scientific investigation.
two.Distribution: The zebrafish is native to the streams of the southeastern Himalayan region., such as the countries Pakistan, Bangladesh, Nepal, and Myanmar. It arose in the Ganges region in Eastern India. It typically inhabits streams, canals, ditches, ponds, and slow-moving to stagnant water bodies, such as rice fields. Zebrafish have been introduced to parts of the United States, presumably by deliberate release or by escape from fish farms. They have also been sighted in Colombia.
three.Description: The fish is named for the five uniform, pigmented, horizontal blue stripes on the side of the physique, all of which extend to the finish of the caudal fin. Its shape can be described as fusiform and laterally compressed, with its mouth directed upwards. Males are torpedo shaped and have gold stripes between the blue stripes females have a larger, whitish belly and have silver stripes instead of gold. Adult females will exhibit a little genital papilla in front of the anal fin origin. The zebrafish can grow to six.four centimetres (two.5 in), even though it is uncommon for them to grow previous 4 centimetres in captivity.
The approximate generation time for the Danio is 3–4 months. It has been observed that there have to be a male present in order for ovulation and spawning of eggs to take place. Females are able to spawn as usually as 2–3 days with hundreds of eggs becoming laid in every clutch. Upon release from the mother, developmental methods will be produced, nevertheless with no the presence of sperm development will stop following the 1st couple of embryonic cleavages. Fertilized eggs will almost immediately turn into transparent, which is an important characteristic yielding D. rerio as a hassle-free research model. Improvement quickly progresses, with precursors to all key organs appearing inside 36 hours of fertilization. Hatching will take spot anyplace from 48–72 hours post-fertilization, based on the internal situations of the embryo itself and the external temperature (ideally 28.five °C). Swimming and feeding behavior are observed to happen around 72 hours post-fertilization. The sex of juvenile zebrafish can not be distinguished except by dissection, and the genetic sex determinants are not clearly understood. The range of life-span for a zebrafish in captivity is around 2–3 years, despite the fact that in perfect situations, they might reside up to five years. The zebrafish is omnivorous, and it primarily eats zooplankton, insects, and phytoplankton. It can consume a range of foods if its main sources are not readily available.
4.Model organism for improvement and genetics: Zebrafish chromatophores, shown right here mediating background adaptation, are studied by scientists D. rerio are a typical and helpful model organism for studies of vertebrate development and gene function. They may possibly supplement greater vertebrate models, such as rats and mice. Pioneering perform of George Streisinger at the University of Oregon established the zebrafish as a model organism its value was consolidated by massive scale forward genetic screens (frequently referred to as the Tübingen/Boston screens). The scholarly journal Development devoted an concern to investigation utilizing the fish in celebration of this landmark. An on-line database of zebrafish genetic, genomic, and developmental information, the Zebrafish Info Network (ZFIN), has been established. D. rerio is one particular of the couple of species of fish to have been flown into space.
A Zebrafish Pigment Mutant. The mutant called bleached blond was made by insertional mutagenesis. The embryos in the image are 4 days old. At the top is a wild-kind embryo, under is the mutant. The mutant lacks black pigment in the melanocytes due to the fact it fails to synthesise melanin properly.
Investigation with D. rerio has allowed advances in the fields of developmental biology, oncology, toxicology, reproductive studies, teratology, genetics, neurobiology, environmental sciences, stem cell and regenerative medicine, and evolutionary theory. Probably its greatest advantages for use in the laboratory as a model program come from its now sequenced genetic code, effectively understood, easily observable and testable developmental behaviors, and the availability of properly-characterized mutants. Zebrafish embryonic improvement supplies positive aspects more than other vertebrate model organisms as effectively. Although the general generation time of zebrafish is comparable to that of mice, zebrafish embryos develop swiftly, progressing from eggs to larvae in below three days. The embryos are massive, robust, and transparent and develop externally to the mother, qualities which all facilitate experimental manipulation and observation. Their practically continual size throughout early development facilitates simple staining strategies, and drugs may possibly be administered by adding directly to the tank. Unfertilized eggs can be created to divide, and the two-celled embryo fused into a single cell, making a completely homozygous embryo.
See hyperlink for pigmentation mutants of D rerio: www.nature.com/hdy/journal/v97/n3/fig_tab/6800867f5.html#…
A common reverse genetics strategy is to decrease gene expression or modify splicing in zebrafish employing Morpholino antisense technologies. Morpholino oligonucleotides are steady, synthetic macromolecules that include the very same bases as DNA or RNA by binding to complementary RNA sequences, they reduce the expression of certain genes. The journal Genesis devoted an problem to research making use of Morpholino oligos, mostly in D. rerio. Morpholino oligonucleotides can be injected into one particular cell of a zebrafish embryo following the 32-cell stage, making an organism in which gene expression is reduced in only the cells descended from the injected cell. Nonetheless, cells in the early embryo (<32 cells) are interpermeable to large molecules, permitting diffusion of Morpholinos among cells. A known difficulty with gene knockdowns in zebrafish is that, due to the fact the genome underwent a duplication after the divergence of ray-finned fishes and lobe-finned fishes, it is not always effortless to silence the activity one particular of the two gene paralogs reliably due to complementation by the other paralog.
Regardless of the complications of the zebrafish genome a quantity of commercially available global platforms for analysis of each gene expression by microarrays and promoter regulation utilizing ChIP-on-chip exist.
Zebrafish have the capability to regenerate fins, skin, the heart, and the brain (in larval stages). Zebrafish have also been discovered to regenerate photoreceptors and retinal neurons following injury. The mechanisms of this regeneration are unknown, but are currently becoming studied. Researchers frequently reduce the dorsal and ventral tail fins and analyze their regrowth to test for mutations. This investigation is major the scientific community in the understanding of healing/repair mechanisms in vertebrates.
5.Recent developments: In October 2001, researchers from the University of Oklahoma published the comprehensive mitochondrial DNA sequence of D. rerio. The length of the zebrafish mitochondrial genome is 16,596 base pairs. This is within 100 base pairs of other related species of fish, and it is notably only 18 bp longer than the goldfish (Carassius auratus) and 21 bp longer than the carp (Cyprinus carpio). The zebrafish gene order and content is identical to the common vertebrate form of mitochondrial DNA. It includes 13 protein-coding genes and a noncoding control area containing the origin of replication for the heavy strand. In between a grouping of five tRNA genes, a sequence resembling vertebrate origin of light strand replication is discovered. In comparing the nucleotide sequence to other vertebrates it is hard to draw any evolutionary conclusions because it is tough to decide as to whether base pair changes have adaptive significance.
In December 2005, a study of the golden strain identified the gene responsible for the uncommon pigmentation of this strain as SLC24A5, a solute carrier that appeared to be essential for melanin production, and confirmed its function with a Morpholino knockdown. The orthologous gene was then characterized in humans and a 1 base pair distinction was located to segregate strongly amongst fair-skinned Europeans and dark-skinned Africans. This study featured on the cover of the academic journal Science and demonstrates the energy of zebrafish as a model organism in the relatively new field of comparative genomics.
In January 2007, Chinese researchers at Fudan University raised genetically modified fish that can detect estrogen pollution in lakes and rivers, showing environmental officials what waterways want to be treated for the substance, which is linked to male infertility. Song Houyan and Zhong Tao, professors at Fudan’s molecular medicine lab, spent three years cloning estrogen-sensitive genes and injecting them into the fertile eggs of zebrafish. The modified fish turn green if they are placed into water that is polluted by estrogen.
On August 1, 2007, researchers at University College London stated they had grown in the laboratory a kind of adult stem cell discovered in the eyes of fish and mammals that develops into neurons in the retina. These cells could be injected in the eye to treat all diseases exactly where the retinal neurons are broken — nearly every illness of the eye, like macular degeneration, glaucoma, and diabetes-associated blindness. Harm to the retina — the part of the eye that sends messages to the brain — is accountable for most instances of sight loss. The researchers studied Müller glial cells in the eyes of humans aged from 18 months to 91 years and had been capable to develop them into all varieties of neurons located in the retina. They have been also in a position to grow them very easily in the lab, they reported in the journal Stem Cells. The cells have been tested in rats with diseased retinas, where they successfully migrated into the retina and took on the characteristics of the surrounding neurons. Now the group is working on the same approach in humans.
In February 2008, researchers at Children’s Hospital Boston reported in the journal Cell Stem Cell the improvement of a new strain of zebrafish, named Casper, with see-through bodies. This enables for detailed visualization of individual blood stem cells and metastasizing (spreading) cancer cells within a living adult organism. Because the function of a lot of genes are shared amongst fish and humans, this tool is expected to yield insight into human ailments such as leukemia and other cancers.
In April 2009, Researchers at the Institute of Genomics and Integrative Biology, Delhi announced the sequencing of the wild-sort strain of Zebrafish, total with about 1.7 billion genetic alphabets.
Nikon AF-D 60mm F2.8 Macro
There is one biochemistry firm spend our lab (US dollars) to get the rights to place this photo on their site and their product fliers. 0808.2009
(Posted by a China Sourcing Agent)